Sonntag 21. November 2010, 14:59
Sonntag 21. November 2010, 15:16
Federico hat geschrieben:An dieser Stelle wieder einmal der Hinweis: Olivier Ameisen dosierte 22 Monate 175mg, im 23. Monat erreichte er mit der Dosierung von 275mg erstmals „Gleichgültigkeit gegenüber Alkohol“.
Aims: To test whether the dose-dependent motivation-suppressing effect of baclofen in animals could be transposed to humans, and suppress craving and sustain abstinence. Methods: Neurologists safely use up to 300 mg/day (10 times the dosage currently used for alcohol dependence) of high-dose oral baclofen, to control spasticity, in order to avoid invasive therapy. I am a physician with alcohol dependence and comorbid anxiety. I self-prescribed high-dose baclofen, starting at 30 mg/day, with 20 mg increments every third day and an (optional) additional 20–40 mg/day for cravings. Results: Cravings became easier to combat. After reaching the craving-suppression dose of 270 mg/day (3.6 mg/kg) after 5 weeks, I became and have remained free of alcohol dependence symptoms effortlessly for the ninth consecutive month. Anxiety is well controlled. Somnolence disappeared with a dosage reduction to 120 mg/day, now used for the eighth consecutive month. Conclusions: High-dose baclofen induced complete and prolonged suppression of symptoms and consequences of alcohol dependence, and relieved anxiety. This model, integrating cure and well-being, should be tested in randomized trials, under medical surveillance. It offers a new concept: medication-induced, dose-dependent, complete and prolonged suppression of substance-dependence symptoms with alleviation of comorbid anxiety
On January 9, 2004, day 1 of post-relapse abstinence, I started oral baclofen monotherapy: 10 mg three times daily (30 mg/day), adding 20 mg/day every third day; optional 20–40 mg/day p.r.n. at a time was available for cravings or important inter-current stress or anxiety. Since cravings appeared during afternoons or evenings, dosages were divided unequally: lower in mornings, i.e. on day 31 (230 mg/day) I took 50 mg, then 90 mg, then 90 mg.
On day 37 (February 14, 2004), on 270 mg/day of baclofen (3.6 mg/kg), I experienced no craving or desire for alcohol for the first time in my alcoholic life. Even in a restaurant with friends, I was indifferent to people drinking. This had never occurred before. Somnolence prevented me from increasing the dosage of baclofen further, and there was no need for the extra 20–40 mg dose. For 12 days, at 270 mg/day, absence of craving persisted, and I remained indifferent to alcohol. In this condition, somnolence became an inconvenient side-effect, and I therefore progressively reduced the dosage to 120 mg/day (1.6 mg/kg) from days 49–63. Since day 63 I have stabilized the dosage around this value with occasional additions of 40 mg p.r.n. in stressful situations. I have not experienced somnolence again; muscular weakness never occurred and there were no other side-effects. Blood tests remained within normal limits
Sonntag 21. November 2010, 16:05
Dienstag 23. November 2010, 20:14
Donnerstag 25. November 2010, 15:58
Freitag 26. November 2010, 12:11
Sonntag 28. November 2010, 12:47
Sonntag 28. November 2010, 19:48
Martin27 hat geschrieben:Ich nehme jetzt 4 x 50mg Baclofen täglich und bemerke derzeit keine besondere Haupt- oder Nebenwirkungen abgesehen von etwas Müdigkeit.
Macht es eurer Meinung nach Sinn die Gesamtdosis noch stärker aufzuteilen?
Sonntag 28. November 2010, 20:12
Sonntag 28. November 2010, 22:29
Martin27 hat geschrieben:Hi emelie,
zuerst einmal Gratulation zu deinem Erfolg in Bezug auf Alk und Benzos!
Ich bin nicht beim Runter- sondern beim Raufdosieren. ^^ Es ist mein zweiter Anlauf und ich bin bereit bis auf max. 375mg Baclofen / Tag - aufgeteilt auf ca. 5-6 Einzeldosen - zu gehen. Meine Toleranz ist sehr hoch und bis jetzt sind die Nebenwirkungen durchwegs tolerierbar.
Ich würde bei Erfolg ("Gleichgültigkeit" gegenüber Alkohol) ca. zwei Monate auf dieser Dosis bleiben und danach langsam und vorsichtig auf eine - hoffentlich deutlich niedrigere - Erhaltungsdosis gehen.
lG, Martin