2013 Self-Intoxication with Baclofen in Alcohol-Dependent...

Oxford Journals Medicine Alcohol and Alcoholism Advance Access 10.1093/alcalc/agt169

Self-Intoxication with Baclofen in Alcohol-Dependent Patients with Co-existing Psychiatric Illness: An Emergency Department Case Series

Nicolas Franchitto, Fanny Pelissier, Dominique Lauque, Nicolas Simon and Christophe Lançon

Poisons and Substance Abuse Treatment Centre, Toulouse-Purpan University Hospital, 31059 Toulouse, France
Emergency Department, Toulouse-Purpan University Hospital, 31059 Toulouse, France
Department of Addictology University Hospital Sainte Marguerite, 13009 Marseille, France

Meine Meinung:
Klingt erstmal ganz schrecklich, spricht aber letztendlich für die Sicherheit von Baclofen in der Behandlung der Alkoholabhängigkeit. Wenn man liest: baclofen was 340 mg (range 140–800 mg). Three patients who had co-ingested benzodiazepines had a decreased level of consciousness (Glasgow Coma Scale <8) and flumazenil had been given to reverse coma. Blood alcohol concentration, requested for all patients, was positive in three (ranging from 153 to 495 mg/100 ml). Gastric lavage was performed in two cases. All patients made a full recovery wird deutlich, wie sicher Baclofen tatsächlich ist.

LG Federico