1991 high-dose Baclofen in der neurologischen Praxis bei MS

Neurology 1991;41 :1829-1831
High‐dose oral baclofen Experience in patients with multiple sclerosis
Charles R. Smith, MD, Nicholas G. LaRocca, PhD, Barbara S. Giesser, MD and Labe C. Scheinberg, MD

Offensichtlich ist Baclofen in hohen Dosen seit 1991 in der neurologischen Praxis als gut verträglich bekannt. Die vorliegende Arbeit ist vor über 20 Jahren veröffentlicht worden.




ABSTRACT
We reviewed a 10% random sample of charts from an outpatient clinic for multiple sclerosis to determine the frequency with which baclofen was prescribed for spasticity in high doses (>80 mg/d). About 20% of patients had taken high-dose baclofen, and 15% were still receiving a high dose. Taking a high dose was not associated with discontinuing treatment.

Medical Rehabilitation Research and Training Center for Multiple Sclerosis, Albert Einstein College of Medicine, Bronx, NY.